UNAIR NEWS – The research team of Technology-Based Beginner Entrepreneur Program (CPPBT) from Faculty of Veterinary Medicine of 51动漫 held a product introduction event in the form of听“Gripeweed Extract to Resist Antibiotic Resistant Enterotoxigenic Escherichia Coli.” The听product by UNAIR CPPBT Team UNAIR was named “Bio Immuno Formula”.
The event held on Saturday 16 September 2017 at Fave Hotel Tuban is a part of the program: Technology-Based Beginner Entrepreneur (CPPBT), Directorate of Technology Based Enterprise, General Directorate of Innovation, Kemenristekdikti in cooperation with Research and Innovation Institute (LPI) 51动漫.
Attending the event were the farming entrepreneurs and some livestock farmers in East Java.听The committee actually invited only 30 farmers / entrepreneurs, but there were more than 50 people attending.听They are very enthusiastic listening to the researchers of UNAIR CPPBT as speakers.听The research team is chaired by Dr.听Ir.听Sri Hidanah, MS., with members Emy Koestanti Sabdoningrum, Drh.M.Kes and Retno Sri Wahjuni, Drh., MS.
The participants were enthusiastic because of the interesting topic of study.听Moreover, the government will impose a ban on the use of antibiotics in the cultivation of livestock.听So farmers start looking for antibiotic replacement products for their farming business.
Farmers and entrepreneurs in East Java in UNAIR CPPBT research product introduction with the marketing and the committee.听(Photo: Doc CPPBT)
This activity involved undergraduate students of FKH UNAIR and Veterinary Agribusiness master program. The keynote speaker was a professor of FKH UNAIR Prof.听Sri Agus Sujarwo, Ph.D., who presents “Resistant Germs as an Impact of Irrational Use of Antibiotics”.听Then Dr.听Rochmah Kurnijasanti, drh., M.Si explained about “Gripeweed Extract”.
After the presentation, there was a discussion and then UNAIR CPPBT team gave the example of “Bio Imuno Formula” to the participants who attended.听Because the CPPBT Team only provided 30听pack of听products, the participants who have not got it took it in FKH UNAIR or it will be sent to them.
Explained by Head of Research Team CPPBT UNAIR, Dr.听Ir.听Sri Hidanah, MS., That this gripeweed extract product is really needed because chemicals on the market is not optimal as antimicrobial for the eradication or enterotoxin therapy of听Escherichia coli which is resistant to antibiotics.听Chemicals as antibiotic diarrheal diseases caused by enterotoxigenic听Escherichia coli听have many side effects such as resistance or the body becomes resistant to antibiotics, making it difficult to treat.
Dr.听Sri Hidanah said the ability of gripeweed extract to kill the bacteria was from the active antibacterial substances, such as听tannins, saponins,and听alkaloids.听Then听flavonoids听serves as an听immunomodulator听that plays a role to boost the immune system and improve the immune system whose function is disrupted.
“Flavonoids听that inhibits the growth of bacteria by acting as the enzyme inhibitor by hampering production of energy and and听nucleic听acid听or protein,” added Sri Hidanah.
While听the tannin听compounds听have a mechanism of action of inhibiting and killing bacterial growth through reaction with membrane cells and the destruction or inactivation of the function of genetic material, toxic and the properties against bacterial cell membranes, by way of inhibiting certain enzymes.
PARTICIPANTS of 听the event 听(Photo: Doc CPPBT)
Saponins听can increase the permeability of bacterial cell membranes, so it can alter membrane structure and function, causing membrane protein denaturation so that cell membranes will be damaged and lysed.听While听alkaloids听are toxic to microbes, so they are effective to kill gram negative and gram positive bacteria.
”听This听alkaloid听works as an antibacteria by destroying the听peptidoglycan听component of听the bacterial cell, so that the cell wall layer is not completely formed and causes the cell’s death,” he added.
The gripeweed extract products will not cause resistance, it is safe and effective compared to chemical products for听听antibiotic therapy of antibiotic resistant听Escherichia coli听antimicrobial.听This gripeweed extract product has 30% dose for five days per orally effective as antibacterial and immunomodulator against enterotoxigenic听Escherichia coli antibiotic resistant in broiler chicken.听(*)
Editor: Bambang Bes
